Dramatic video footage shared on Twitter shows smoke billowing out of the aircraft on the ground next to the flaming house.
The wreckage is smouldering as firefighters work at the scene of the crash, which took place in a neighbourhood in Lyon Township, west of Detroit, in the US state of Michigan.
Firefighters urged residents to stay away from the crash site calling it an “active incident” with paramedics and police also on scene.
The local police force have said the pilot was believed to be still inside the plane.
The residents were reported to have escaped the house.
A spokesperson for Lyon Township Fire Department (LTFD) said: “LTFD is responding to a plane that crashed into a house and is on fire. More updates to follow.
“This is an active incident with multiple agencies responding, please avoid the area if you see the location.”
The crash happened at about 3.30pm local time on Saturday.
A post on the Oakland County Sheriff’s Office’s Facebook page stated: “Plane crash reported in Lyon Township Lyon Township.
“Deputies and Fire Department are responding to a plane crash into a residential home in the 57600 block of Russet.
“The residence is fully engulfed.
“All residents are reported to be out of the home.
“The pilot is believed to still be in the plane.
“Information is not available on occupants of the plane or type of plane at this time.
“The FAA (Federal Aviation Administration) has been contacted.”
MORE TO FOLLOW…